Advanced air mobility (AAM) is an emerging field that envisions highly automated, high-tempo, passenger-carrying aircraft operating in urban environments.Numerous stakeholders have emerged in this space, each proposing unique concepts of operation (CONOPS).While this technology will enable a revolutionary leap in modern transportation, many challen
Glioblastoma multiforme (GBM) is rare and fatal glioma with limited treatment options.Treatments provide minimal improvement in prognosis and only 6.8% of GBM patients have a life expectancy greater than five years.Surgical resection of this malignant glioma is difficult due to its highly invasive nature and follow-up radiotherapy Manganese with co
ABSTRACT The molecular mechanisms underlying how SUD2 recruits other proteins of severe acute respiratory B-3 syndrome coronavirus 2 (SARS-CoV-2) to exert its G-quadruplex (G4)-dependent pathogenic function is unknown.Herein, Nsp5 was singled out as a binding partner of the SUD2-N+M domains (SUD2core) with high affinity, through the surface located